Abstract:
Structural equation modeling was used to assess resting state temporal lobe functional connectivity in 23 healthy adult participants. Four regions implicated in temporal lobe epilepsy (TLE) were modeled (hippocampus, amygdala, anterior insula, and dorsal thalamic nucleus) from z-saga functional datasets of resting participants. Amygala demonstrated strong negative path weighting (-.71) on the anterior insula, possibly reflecting participants’ fluctuating attention between external stimuli and interoceptive sensation. Although hippocampus and amygdala have previously demonstrated task-related functional connectivity, no significant connectivity was observed between these regions at rest. Future work will test the validity of this model for TLE populations.
Reference:
abstract G. A. James, S. M. LaConte, R. C. Craddock, T. R. Henry, H. S. Mayberg, X. P. Hu. Structural equation modeling of resting-state temporal lobe functional connectivity. In Proceedings 15th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Berlin, page 1988, 2007. [bibtex]
Bibtex Entry:
@inproceedings{Berlin1988,
Author = {James, G. A. and LaConte, S. M. and Craddock, R. C. and Henry, T. R. and Mayberg, H. S. and Hu, X. P.},
Title ={Structural equation modeling of resting-state temporal lobe functional connectivity},
BookTitle = {Proceedings 15th Scientific Meeting, International Society for Magnetic Resonance in Medicine, Berlin},
Pages = {1988},
Abstract = {Structural equation modeling was used to assess resting state temporal lobe functional connectivity in 23 healthy adult participants. Four regions implicated in temporal lobe epilepsy (TLE) were modeled (hippocampus, amygdala, anterior insula, and dorsal thalamic nucleus) from z-saga functional datasets of resting participants. Amygala demonstrated strong negative path weighting (-.71) on the anterior insula, possibly reflecting participants’ fluctuating attention between external stimuli and interoceptive sensation. Although hippocampus and amygdala have previously demonstrated task-related functional connectivity, no significant connectivity was observed between these regions at rest. Future work will test the validity of this model for TLE populations.},
Keywords = {Berlin1988},
Year = {2007} }